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Clinical application of HPV typing in cervical cancer.
- Source :
-
International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics [Int J Gynaecol Obstet] 1995 Jul; Vol. 49 Suppl, pp. S59-67. - Publication Year :
- 1995
-
Abstract
- Certain human papaillomavirus (HPV) types are major risk factors for the development of cervical neoplasia. The value of HPV DNA testing in the management of patients with disease and in population screening is a subject of controversy. Since the introduction of molecular biology into the HPV field, there have been rapid advances and improvements in HPV diagnosis. The various molecular diagnostic methods for detection of HPV DNA (dot blot hybridization, Southern blot hybridization, in situ hybridization, Hybrid Capture Test, and polymerase chain reaction; PCR) could be selected by taking into consideration some factors such as characteristics of sample, sensitivity of HPV test and expenses. The HPV DNA testing would be a clinically useful diagnostic method, when used in conjunction with the Pap smear in population screening or in conjunction with cytology and colposcopy to identify the women infected with high-risk HPVs or women who had equivocal cervical lesions. Despite the confusion, a multitude of reports demonstrate that HPV DNA testing has the clinical utility, and future investigations should be directed at more accurately delineating its role in human health care.
- Subjects :
- DNA, Viral isolation & purification
Female
Humans
Lymphatic Metastasis
Microbiological Techniques
Papillomaviridae isolation & purification
Papillomavirus Infections diagnosis
Papillomavirus Infections pathology
Tumor Virus Infections diagnosis
Tumor Virus Infections pathology
Uterine Cervical Neoplasms pathology
Papillomaviridae classification
Papillomavirus Infections virology
Tumor Virus Infections virology
Uterine Cervical Neoplasms virology
Subjects
Details
- Language :
- English
- ISSN :
- 0020-7292
- Volume :
- 49 Suppl
- Database :
- MEDLINE
- Journal :
- International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics
- Publication Type :
- Academic Journal
- Accession number :
- 7589742
- Full Text :
- https://doi.org/10.1016/0020-7292(95)02411-5