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Inhibition of atherosclerosis and myocardial lesions in the JCR:LA-cp rat by beta, beta'-tetramethylhexadecanedioic acid (MEDICA 16).
- Source :
-
Arteriosclerosis, thrombosis, and vascular biology [Arterioscler Thromb Vasc Biol] 1995 Jul; Vol. 15 (7), pp. 918-23. - Publication Year :
- 1995
-
Abstract
- Atherosclerosis-prone, insulin-resistant JCR:LA-cp male rats were treated from 6 weeks to 39 weeks of age with beta,beta'-tetramethylhexadecanedioic acid (MEDICA 16). Body weights were reduced (13%, P < .001) at 36 weeks without any accompanying decrease in food consumption. The treatment did not cause any significant change in plasma glucose or fasting insulin concentrations. There was a significant decrease in the extreme hyperplasia of the islets of Langerhans (38%, P < .05). The marked VLDL hypertriglyceridemia was decreased by 70% (P < .001), with an accompanying significant reduction in cholesterol concentrations. The severity of raised atherosclerotic lesions on the aortic arch was very markedly reduced (P < .01) in treated rats. This was accompanied by a reduction (P < .01) in the incidence of ischemic myocardial lesions. We conclude that long-term (33 weeks) MEDICA 16 treatment of an animal model for the obesity/insulin-resistant/hyperlipidemic syndrome not only markedly improved lipid metabolism, but also inhibited the development of advanced cardiovascular disease.
- Subjects :
- Animals
Aorta pathology
Arteriosclerosis pathology
Body Weight
Cardiomyopathies pathology
Endothelium, Vascular pathology
Lipids blood
Macrophages pathology
Male
Microscopy, Electron, Scanning
Pancreas pathology
Rats
Rats, Mutant Strains
Arteriosclerosis prevention & control
Cardiomyopathies prevention & control
Palmitic Acids therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1079-5642
- Volume :
- 15
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Arteriosclerosis, thrombosis, and vascular biology
- Publication Type :
- Academic Journal
- Accession number :
- 7600124
- Full Text :
- https://doi.org/10.1161/01.atv.15.7.918