Back to Search
Start Over
Effect of single and multidose cephradine prophylaxis on infectious morbidity of vaginal hysterectomy.
- Source :
-
Obstetrics and gynecology [Obstet Gynecol] 1979 Jan; Vol. 53 (1), pp. 31-5. - Publication Year :
- 1979
-
Abstract
- The administration of cephradine prophylactically to patients who were undergoing vaginal hysterectomies resulted in a marked and significant reduction in the incidence of postoperative infections when compared to a placebo group. Cephradine was the cephalosporin studied because of its unique pharmacodynamic properties, which result in high uterine tissue levels. The protective effect was similar whether 1 g was given preoperatively followed by 500 mg IV q. 6 hours for 4 doses, or a single dose of 2 g IV given approximately 1 hour before surgery. Uterine tissue and serum levels of antibiotic were high and correlated with the degree of protection noted.
- Subjects :
- Adult
Aged
Bacterial Infections epidemiology
Bacterial Infections etiology
Bacteriuria epidemiology
Bacteriuria etiology
Cephradine metabolism
Cephradine therapeutic use
Double-Blind Method
Female
Fever epidemiology
Humans
Middle Aged
Pelvis
Placebos
Postoperative Complications epidemiology
Prospective Studies
Urinary Tract Infections etiology
Uterus metabolism
Bacterial Infections prevention & control
Cephalosporins administration & dosage
Cephradine administration & dosage
Hysterectomy
Hysterectomy, Vaginal
Postoperative Complications prevention & control
Subjects
Details
- Language :
- English
- ISSN :
- 0029-7844
- Volume :
- 53
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Obstetrics and gynecology
- Publication Type :
- Academic Journal
- Accession number :
- 760017