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[Study of serial bronchoalveolar lavage in patients with aspergilloma: cell reaction at the affected sites and penetration of miconazole and flucytosine into the lesion].
- Source :
-
Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases [Kansenshogaku Zasshi] 1995 May; Vol. 69 (5), pp. 517-23. - Publication Year :
- 1995
-
Abstract
- We have performed serial bronchoalveolar lavage (BAL) examination in two patients with asperigilloma and compared that of total cell count and cell population with control groups (5 non-smokers, 10 smokers) and other pulmonary infectious diseases: 7 each with mycoplasmal pneumonia and pulmonary tuberculosis, 6 with bacterial pneumonia, and 5 with chlamydial pneumonia. Miconazole (MCZ) by drip intravenous infusion of 400 mg/day and flucytosine (5-FC) by oral intake of 4.5 to 6.0 g/day were administered to one patient with aspergilloma, and we studied the serum and BALF concentration about 5 hours after administration. The followings results were obtained: 1. In aspergilloma, the cell population of neutrophils in BALF increased compared with control groups (p < 0.01) and other pulmonary infectious disease. 2. The serum and BALF levels of MCZ ranged from 0.1 to 0.3 micrograms/ml, < 0.1 14.4 micrograms/ml, respectively. On the other hand, the serum and BALF levels of 5-FC ranged from < 0.2 to 9.3 micrograms/ml, and < 0.4 to 1.5 micrograms/ml, respectively. From these results, we consider that neutrophils play the main role in the immune host defense in aspergilloma, and the combination of intracavitary infusion of MCZ and oral administration of 5-FC should be the treatment of choice.
- Subjects :
- Administration, Oral
Adult
Aged
Aspergillosis pathology
Bronchoalveolar Lavage Fluid chemistry
Female
Flucytosine administration & dosage
Humans
Infusions, Intravenous
Lung Diseases, Fungal pathology
Male
Miconazole administration & dosage
Aspergillosis drug therapy
Bronchoalveolar Lavage Fluid cytology
Flucytosine pharmacokinetics
Lung Diseases, Fungal drug therapy
Miconazole pharmacokinetics
Subjects
Details
- Language :
- Japanese
- ISSN :
- 0387-5911
- Volume :
- 69
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases
- Publication Type :
- Academic Journal
- Accession number :
- 7602184
- Full Text :
- https://doi.org/10.11150/kansenshogakuzasshi1970.69.517