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History of thyroid diseases and subsequent thyroid cancer risk.
- Source :
-
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology [Cancer Epidemiol Biomarkers Prev] 1995 Apr-May; Vol. 4 (3), pp. 193-9. - Publication Year :
- 1995
-
Abstract
- A history of benign thyroid diseases has been associated with the risk of thyroid cancer. We have analyzed this issue using data from a case-control study conducted in northern Italy between 1986 and 1992 on 399 incident, histologically confirmed thyroid cancer cases and 617 controls admitted to the hospital for acute, nonneoplastic, non-hormone-related diseases. The overall multivariate relative risk (RR) estimates were 2.8 [95% confidence interval (CI), 0.6-12.4] for previous episodes of thyroiditis, 27.1 (95% CI, 6.5-111.9) for adenoma, 8.2 (95% CI, 3.5-19.1) for goiter, 3.8 (95% CI, 1.4-10.9) for hyperthyroidism, and 1.5 (95% CI, 0.4-5.1) for hypothyroidism when all histotypes were analyzed. The RR for any thyroid disease was 7.7 (95% CI, 4.6-12.8). A family history of thyroid disease was significantly related to thyroid cancer with an RR of 1.6. The RR for having resided in endemic goiter areas was 1.3 for < 20 years of residence and 1.6 for 20 or more years. These associations were somewhat stronger when only papillary, follicular, and mixed papillary/follicular cancers were considered. Analyses of data in separate strata of sex and age suggested that several benign conditions play a more important role in females and in subjects younger than 50 years. Results were similar to the overall ones when papillary and follicular carcinomas were considered separately. The population-attributable risk for any previous thyroid disease was approximately 20% in this Italian population. These results confirm that history of thyroid disease is a relevant indicator of subsequent thyroid cancer risk also in areas at relatively low prevalence of goiter and other thyroid diseases.
- Subjects :
- Adenocarcinoma, Follicular epidemiology
Adenocarcinoma, Follicular etiology
Adenocarcinoma, Follicular pathology
Adolescent
Adult
Aged
Carcinoma, Papillary epidemiology
Carcinoma, Papillary etiology
Carcinoma, Papillary pathology
Carcinoma, Papillary, Follicular epidemiology
Carcinoma, Papillary, Follicular etiology
Carcinoma, Papillary, Follicular pathology
Case-Control Studies
Confidence Intervals
Female
Goiter, Endemic complications
Goiter, Endemic epidemiology
Goiter, Endemic pathology
Humans
Italy epidemiology
Male
Middle Aged
Multivariate Analysis
Risk Factors
Thyroid Diseases epidemiology
Thyroid Diseases pathology
Thyroid Gland pathology
Thyroid Neoplasms epidemiology
Thyroid Neoplasms pathology
Thyroid Diseases complications
Thyroid Neoplasms etiology
Subjects
Details
- Language :
- English
- ISSN :
- 1055-9965
- Volume :
- 4
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
- Publication Type :
- Academic Journal
- Accession number :
- 7606193