Collagen gene expression in radiation interstitial pneumonitis.

Authors :: Bai YH
Wang DW
Cui CB
Ci YP
Cui XM
Xiong CQ
Zhang ZS
Liu BC
Source :: Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer [J Environ Pathol Toxicol Oncol] 1994; Vol. 13 (4), pp. 231-4.
Publication Year :: 1994
Abstract: By using type I and type III collagen cDNA probe and cDNA-mRNA in situ hybridization, we observed the changes of rat lung alpha 1(I) and alpha 1(III) collagen gene expression in radiation interstitial pneumonitis. The results showed that the expressed cell of type I and type III collagen were scattered within the fibroblasts in the thickened interalveolar walls. The type I and type III collagen mRNA content in irradiated animals were higher than those in the controls at 0.5, 1, 2, 3, 6, and 12 months.

Subjects :: Animals
Collagen biosynthesis
Gene Expression
In Situ Hybridization
Male
RNA, Messenger genetics
Rats
Rats, Wistar
Collagen genetics
Radiation Pneumonitis genetics

Language :: English
ISSN :: 0731-8898
Volume :: 13
Issue :: 4
Database :: MEDLINE
Journal :: Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer
Publication Type :: Academic Journal
Accession number :: 7658331

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