N-(indol-3-ylglyoxylyl)amino acid ester derivatives. Synthesis and interaction properties at the benzodiazepine receptor.

Authors :: Primofiore G
Da Settimo F
Marini AM
La Motta C
Martini C
Senatore G
Lucacchini A
Source :: Farmaco (Societa chimica italiana : 1989) [Farmaco] 1995 Jan; Vol. 50 (1), pp. 5-12.
Publication Year :: 1995
Abstract: Several N-(indol-3-ylglyoxylyl)alanine and glycine ester derivatives were prepared to evaluate the influence of the ester group size both on affinity and on activity at the benzodiazepine receptor. Moreover, indol-3-ylglyoxylic acid esters, closely related to 3-alkoxy-beta-carbolines, were synthesized and tested in vitro on the benzodiazepine receptor.

Subjects :: Animals
Cattle
Flunitrazepam metabolism
Indoles metabolism
Structure-Activity Relationship
Indoles chemical synthesis
Receptors, GABA-A metabolism

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