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Comparison of technetium-99m methoxyisobutylisonitrile and gallium-67 citrate scanning in the assessment of lymphomas.
Comparison of technetium-99m methoxyisobutylisonitrile and gallium-67 citrate scanning in the assessment of lymphomas.
- Source :
-
European journal of nuclear medicine [Eur J Nucl Med] 1995 Feb; Vol. 22 (2), pp. 126-31. - Publication Year :
- 1995
-
Abstract
- The aim of this study was to compare the value of scintigraphy using technetium-99m methoxyisobutylisonitrile (MIBI) with that of scintigraphy using gallium-67 citrate in the assessment of Hodgkin's disease and non-Hodgkin's lymphoma and to relate these results with those of CT scan and MRI. Fifty-eight patients were included either for a follow-up examination or for monitoring of their treatment. Twenty-three residual masses were studied. A whole-body scan was performed, followed by single-photon emission computed tomography (SPET) 20 min after injection of 740 MBq of 99mTc-MIBI and 72 h after injection of 185 MBq of 67Ga citrate. The overall sensitivity of 99mTc-MIBI and 67Ga citrate was 71% and 68%, respectively, and the overall specificity was 76% and 44%, respectively. For residual masses, the sensitivity was 44% with both tracers and the specificity was 80% with 99mTc-MIBI and 53% with 67Ga citrate. The positive predictive values were 85% and 68% and the negative predictive values were 59% and 44%, respectively. The signal-to-background ratio was 1.5 for 99mTc-MIBI and 2 for 67Ga citrate. At present, 99mTc-MIBI cannot replace 67Ga citrate in the assessment of lymphomas.
- Subjects :
- Adult
Biopsy
Citric Acid
Female
Hodgkin Disease diagnosis
Humans
Lymphoma, Non-Hodgkin diagnosis
Magnetic Resonance Imaging
Male
Predictive Value of Tests
Sensitivity and Specificity
Tomography, Emission-Computed, Single-Photon
Tomography, X-Ray Computed
Citrates
Gallium Radioisotopes
Hodgkin Disease diagnostic imaging
Lymphoma, Non-Hodgkin diagnostic imaging
Technetium Tc 99m Sestamibi
Subjects
Details
- Language :
- English
- ISSN :
- 0340-6997
- Volume :
- 22
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- European journal of nuclear medicine
- Publication Type :
- Academic Journal
- Accession number :
- 7758499
- Full Text :
- https://doi.org/10.1007/BF00838942