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Renal failure during acute toxicity produced by tullidora ingestion (Karwinskia humboldtiana).
- Source :
-
General pharmacology [Gen Pharmacol] 1995 May; Vol. 26 (3), pp. 649-53. - Publication Year :
- 1995
-
Abstract
- 1. Acute effects of Karwinskia humboldtiana (Kh) were studied in some renal functions and structural patterns of renal tissue. 2. Haemodynamic changes were observed with decrements of the glomerular filtration rate, renal plasma flow and filtration fraction during acute intoxication. 3. A marked increment in the fractional excretion of sodium was observed in the rats treated with tullidora fruits (Kh). 4. Cloudy swelling and hydropic degeneration was seen 72 hr after intoxication, mainly in the proximal convoluted tubules.
- Subjects :
- Animals
Kidney pathology
Kidney Function Tests
Kidney Tubules, Proximal pathology
Male
Plant Poisoning pathology
Rats
Rats, Wistar
Renal Circulation drug effects
Renal Insufficiency pathology
Renal Insufficiency physiopathology
Sodium urine
Plant Poisoning physiopathology
Plants, Toxic
Renal Insufficiency chemically induced
Subjects
Details
- Language :
- English
- ISSN :
- 0306-3623
- Volume :
- 26
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- General pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 7789741
- Full Text :
- https://doi.org/10.1016/0306-3623(95)94004-z