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Anti-tumor action of dietary restriction is lesion-dependent in male Fischer 344 rats.
- Source :
-
The journals of gerontology. Series A, Biological sciences and medical sciences [J Gerontol A Biol Sci Med Sci] 1995 Mar; Vol. 50 (2), pp. B72-7. - Publication Year :
- 1995
-
Abstract
- The effects of dietary restriction (DR) on spontaneous oncogenesis in male Fischer 344 rats were analyzed. Previously reported analyses of studies carried out in our laboratory demonstrated that DR reduces the incidence and delays the onset, but not the progression, of leukemia in male F344 rats. In this report, the influence of DR on pituitary tumors, adrenal pheochromocytoma, pancreatic islet cell tumors, and interstitial cell tumors of the testis was analyzed. DR reduced the relative incidence (relative onset rates) and delayed the onset of the four tumors. DR also retarded the progression (duration from onset to death) of pituitary tumors and pheochromocytoma. DR has delayed the onset of all tumors of the male F344 rat so far analyzed, but its effect on tumor progression appears to be lesion-dependent.
- Subjects :
- Adenoma, Islet Cell etiology
Adenoma, Islet Cell physiopathology
Adrenal Gland Neoplasms etiology
Adrenal Gland Neoplasms physiopathology
Age of Onset
Animals
Disease Progression
Leydig Cell Tumor etiology
Leydig Cell Tumor physiopathology
Male
Neoplasms, Experimental physiopathology
Pancreatic Neoplasms etiology
Pancreatic Neoplasms physiopathology
Pheochromocytoma etiology
Pheochromocytoma physiopathology
Pituitary Neoplasms etiology
Pituitary Neoplasms physiopathology
Rats
Rats, Inbred F344
Survival Rate
Testicular Neoplasms etiology
Testicular Neoplasms physiopathology
Diet
Energy Intake physiology
Neoplasms, Experimental etiology
Subjects
Details
- Language :
- English
- ISSN :
- 1079-5006
- Volume :
- 50
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- The journals of gerontology. Series A, Biological sciences and medical sciences
- Publication Type :
- Academic Journal
- Accession number :
- 7874582
- Full Text :
- https://doi.org/10.1093/gerona/50a.2.b72