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Synthesis and anticonvulsant activity of some new thiosemicarbazone and 4-thiazolidone derivatives bearing an isatin moiety.
- Source :
-
Farmaco (Societa chimica italiana : 1989) [Farmaco] 1994 Dec; Vol. 49 (12), pp. 819-22. - Publication Year :
- 1994
-
Abstract
- A series of 3-thiosemicarbazono-2-indolinones and 3-(4-thiazolidone-2-hydrazono)-2-indolinones was synthesized by condensation of various isatin derivatives with 4-substituted 3-thiosemicarbazides and cyclization of the products by monochloroacetic acid or ethyl alpha-bromoacetate. In the present work we report on the structure determination and anticonvulsant evaluation of the title compounds.
- Subjects :
- Animals
Anticonvulsants chemistry
Anticonvulsants pharmacology
Magnetic Resonance Spectroscopy
Mice
Structure-Activity Relationship
Thiazoles chemistry
Thiazoles pharmacology
Thiosemicarbazones chemistry
Thiosemicarbazones pharmacology
Anticonvulsants chemical synthesis
Isatin analogs & derivatives
Thiazoles chemical synthesis
Thiosemicarbazones chemical synthesis
Subjects
Details
- Language :
- English
- ISSN :
- 0014-827X
- Volume :
- 49
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Farmaco (Societa chimica italiana : 1989)
- Publication Type :
- Academic Journal
- Accession number :
- 7893339