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Coenzyme A glutathione disulfide. A potent vasoconstrictor derived from the adrenal gland.
- Source :
-
Circulation research [Circ Res] 1995 Apr; Vol. 76 (4), pp. 675-80. - Publication Year :
- 1995
-
Abstract
- The adrenal gland is involved in the regulation of vascular tone by secretion of vasoactive agents such as catecholamines, neuropeptide Y, or endogenous ouabain. A further potent vasoconstrictor is isolated from bovine adrenal glands and is identified by chromatography, mass spectrometry, UV spectroscopy, and enzymatic cleavage as coenzyme A glutathione disulfide (CoASSG). CoASSG is found in chromaffin granules of adrenal glands and is released from adrenal medulla slices by carbachol. At a concentration of 10(-12) mol/L CoASSG increases renal vascular resistance. Intra-aortic injection of 5 x 10(-10) mol CoASSG increases blood pressure in the intact animal. Besides its vasopressor properties, this substance potentiates the effects of angiotensin II on vascular tone. It is concluded that CoASSG could play a role in blood pressure regulation not only by direct effects but also by modulation of the action of angiotensin II.
- Subjects :
- Adrenal Medulla chemistry
Adrenal Medulla drug effects
Adrenal Medulla metabolism
Animals
Blood Pressure drug effects
Calcium analysis
Carbachol pharmacology
Cattle
Chromaffin Granules chemistry
Chromaffin Granules drug effects
Chromaffin Granules metabolism
Chromatography, High Pressure Liquid
Coenzyme A pharmacology
Hemodynamics
In Vitro Techniques
Kidney drug effects
Mass Spectrometry
Muscle, Smooth, Vascular chemistry
Muscle, Smooth, Vascular cytology
Perfusion
Rats
Spectrophotometry, Ultraviolet
Stimulation, Chemical
Vascular Resistance drug effects
Vasoconstrictor Agents pharmacology
Adrenal Glands chemistry
Coenzyme A isolation & purification
Vasoconstrictor Agents isolation & purification
Subjects
Details
- Language :
- English
- ISSN :
- 0009-7330
- Volume :
- 76
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Circulation research
- Publication Type :
- Academic Journal
- Accession number :
- 7895341
- Full Text :
- https://doi.org/10.1161/01.res.76.4.675