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Pathobiology of focal sclerosis.

Authors :
Wolthuis A
van Goor H
Weening JJ
Grond J
Source :
Current opinion in nephrology and hypertension [Curr Opin Nephrol Hypertens] 1993 May; Vol. 2 (3), pp. 458-64.
Publication Year :
1993

Abstract

This paper briefly reviews recent experimental data derived from work in animals and cell cultures that have increased our understanding of the pathobiologic pathways leading to focal sclerosis. These pathways include glomerular visceral epithelial cell damage, leukocyte infiltration, hyperplasia and matrix accumulation in the mesangium, and endothelial injury.

Subjects

Subjects :
Animals
Glomerulosclerosis, Focal Segmental metabolism
Glomerulosclerosis, Focal Segmental physiopathology
Humans
Kidney Glomerulus pathology
Kidney Glomerulus physiopathology
Glomerulosclerosis, Focal Segmental pathology

Details

Language :
English
ISSN :
1062-4821
Volume :
2
Issue :
3
Database :
MEDLINE
Journal :
Current opinion in nephrology and hypertension
Publication Type :
Academic Journal
Accession number :
7922206
Full Text :
https://doi.org/10.1097/00041552-199305000-00014
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