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Association of hippocampal sclerosis with cortical dysgenesis in patients with epilepsy.
- Source :
-
Neurology [Neurology] 1994 Oct; Vol. 44 (10), pp. 1841-5. - Publication Year :
- 1994
-
Abstract
- The possible dual occurrence of hippocampal sclerosis (HS) and other structural lesions (especially cortical dysgenesis [CD]) is well established in patients with chronic partial epilepsy. We describe the frequency of additional CD in a series of 100 patients with evidence of HS, using volumetric MRI. Additional, often subtle, CD was present in 15 patients: subependymal heterotopia (six), forme fruste of tuberous sclerosis (two), focal macrogyria (two), focal cortical dysplasia (one), laminar heterotopia (one), bilateral schizencephaly (one), and simplified gyral patterns (two). In contrast, in 46 healthy volunteers, only one had possible CD (p < 0.05). Only 2 of 15 patients had a history of childhood febrile convulsions. HS is a heterogeneous condition; patients being evaluated for temporal lobe surgery should be carefully screened for additional CD using appropriate MR techniques.
- Subjects :
- Adolescent
Adult
Brain Diseases complications
Brain Diseases diagnosis
Brain Diseases surgery
Cerebral Cortex surgery
Child
Choristoma complications
Choristoma diagnosis
Choristoma surgery
Chronic Disease
Cohort Studies
Female
Follow-Up Studies
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Sclerosis complications
Sclerosis diagnosis
Sclerosis surgery
Temporal Lobe surgery
Cerebral Cortex abnormalities
Epilepsies, Partial etiology
Hippocampus pathology
Subjects
Details
- Language :
- English
- ISSN :
- 0028-3878
- Volume :
- 44
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Neurology
- Publication Type :
- Academic Journal
- Accession number :
- 7936233
- Full Text :
- https://doi.org/10.1212/wnl.44.10.1841