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Karyometry of primary and metastatic malignant melanoma. A correlation with cell proliferation.
- Source :
-
The American Journal of dermatopathology [Am J Dermatopathol] 1994 Jun; Vol. 16 (3), pp. 247-52. - Publication Year :
- 1994
-
Abstract
- We used computerized image analysis, immunohistochemistry, and the incorporation of tritiated thymidine to study the relationship between nuclear size and shape and the proliferation of malignant melanoma cells. A total of 30 nonulcerated primary malignant melanomas and 75 of their cutaneous metastases were considered. We found a positive relationship between (a) the 3H-TdR labeling indices and the thickness of the primary malignant melanoma: (b) the nuclear profile areas of primary lesions and their respective metastases; and (c) the size and regularity of the contours of the nuclei. We failed to find a relationship between 3H-TdR indices and the nuclear size of malignant melanoma cells.
Details
- Language :
- English
- ISSN :
- 0193-1091
- Volume :
- 16
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- The American Journal of dermatopathology
- Publication Type :
- Academic Journal
- Accession number :
- 7943630
- Full Text :
- https://doi.org/10.1097/00000372-199406000-00004