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In vivo stimulation of insulin release by succinic acid methyl esters.
- Source :
-
Archives internationales de pharmacodynamie et de therapie [Arch Int Pharmacodyn Ther] 1994 Mar-Apr; Vol. 327 (2), pp. 246-50. - Publication Year :
- 1994
-
Abstract
- Both the monomethyl and dimethyl esters of succinic acid, administered intravenously to fasted and anesthetized rats, caused a rapid increase in plasma insulin. A positive insulin secretory response to succinic acid monomethyl ester was also observed after intraperitoneal injection to fed and conscious rats. On a molar basis, stimulation of the insulin release, evoked by succinic acid esters, represented about twice that caused by D-glucose. It is speculated that succinic acid esters may be efficient insulin secretagogues even in those models of noninsulin-dependent diabetes characterized by a site-specific defect in the transport of D-glucose or in the early steps of its catabolism in the pancreatic B-cell.
Details
- Language :
- English
- ISSN :
- 0003-9780
- Volume :
- 327
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Archives internationales de pharmacodynamie et de therapie
- Publication Type :
- Academic Journal
- Accession number :
- 7979832