A case of severe neonatal thrombocytopenia with schizencephaly associated with anti-HPA-1b and anti-HPA-2a.

Authors :: Kuijpers RW
van den Anker JN
Baerts W
von dem Borne AE
Source :: British journal of haematology [Br J Haematol] 1994 Jul; Vol. 87 (3), pp. 576-9.
Publication Year :: 1994
Abstract: We report a family with a neonate who was severely damaged by intracranial haemorrhages. These probably occurred before the 20th week of gestation. The neonate had a moderate thrombocytopenia. In the maternal serum anti-HPA-1b and anti-HPA-2a alloantibodies were detected. Third-generation assays were applied to identify the alloantibodies. No other cause for the bleeding was found. Probably the combination of anti-HPA-1b and anti-HPA-2a alloantibodies, directed against the platelet fibrinogen receptor and the von Willebrand receptor, respectively, induced a thrombocytopenia and a thrombocytopathy.

Subjects :: Blood Platelets immunology
Cerebral Hemorrhage congenital
Cerebral Hemorrhage immunology
Female
Fetal Diseases etiology
Humans
Infant, Newborn
Platelet Membrane Glycoproteins immunology
Pregnancy
Receptors, Cell Surface immunology
Thrombocytopenia immunology
Antigens, Human Platelet immunology
Brain abnormalities
Cerebral Hemorrhage etiology
Fetomaternal Transfusion immunology
Isoantibodies analysis
Thrombocytopenia congenital

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