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Effects of zinc on hepatic ornithine transcarbamylase (OTC) activity.
- Source :
-
Journal of trace elements and electrolytes in health and disease [J Trace Elem Electrolytes Health Dis] 1993 Dec; Vol. 7 (4), pp. 240-1. - Publication Year :
- 1993
-
Abstract
- The aim of the study was to examine the effects of oral zinc supplementation on liver ornithine transcarbamylase activity (OTC), a key enzyme in the urea cycle, in cirrhotic rats. OTC was studied in two groups of rats treated with carbon tetrachloride (CCl4): the first received zinc in the drinking water during the induction of cirrhosis; the second was the control group. Cirrhotic rats which received zinc supplementation showed an increase in liver OTC activity, positively correlated with serum and hepatic zinc content. The results suggest that zinc dietary supplementation may modify hepatic OTC activity and, therefore, plasma ammonia levels in cirrhotic rats.
- Subjects :
- Ammonia blood
Animals
Carbon Tetrachloride
Disease Models, Animal
Liver drug effects
Liver metabolism
Liver Cirrhosis, Experimental blood
Liver Cirrhosis, Experimental chemically induced
Liver Cirrhosis, Experimental drug therapy
Male
Rats
Rats, Wistar
Zinc blood
Zinc metabolism
Liver enzymology
Liver Cirrhosis, Experimental metabolism
Ornithine Carbamoyltransferase metabolism
Zinc pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0931-2838
- Volume :
- 7
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Journal of trace elements and electrolytes in health and disease
- Publication Type :
- Academic Journal
- Accession number :
- 8019156