Effect of pentoxifylline, a multidrug resistance reversal agent, on haemopoietic stem cell homing.

Authors :: Gude RP
Chitnis MP
Rao SG
Source :: Cell biology international [Cell Biol Int] 1994 Feb; Vol. 18 (2), pp. 79-84.
Publication Year :: 1994
Abstract: This paper investigates the mechanism of mouse haemopoietic stem cell homing into the cytoskeleton depolymerizing agent Pentoxifylline was used, and shown to inhibit stem cell homing. The inhibition was reversible after 6 hours. The results obtained suggest that the haemopoietic stem cell homing receptor is anchored to cytoskeletal support intracellularly.

Subjects :: Animals
Bone Marrow Cells
Cell Movement drug effects
Cells, Cultured
Female
Hematopoietic Stem Cells physiology
Male
Mice
Mice, Inbred Strains
Pentoxifylline toxicity
Specific Pathogen-Free Organisms
Spleen cytology
Hematopoietic Stem Cells drug effects
Pentoxifylline pharmacology

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