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Proliferation of endothelial component of parathyroid gland in multiple endocrine neoplasia type 1. Potential relationship with a mitogenic factor.
- Source :
-
The American journal of pathology [Am J Pathol] 1993 Aug; Vol. 143 (2), pp. 612-7. - Publication Year :
- 1993
-
Abstract
- The basic fibroblast growth factor-like mitogen detected in the plasma of patients with the multiple endocrine neoplasia type 1 (MEN-1) syndrome was found to have a specific mitogenic effect on parathyroid endothelial cells in vitro. To investigate its pathogenic role in humans, the endothelial component of parathyroid glands was evaluated by ultrastructural morphometry in six MEN-1 patients. The results were compared with those found in six patients with uremic hyperparathyroidism (UHPT) and in three subjects with histologically normal glands. Plasma mitogenic activity was found in all MEN-1 patients but not in those with UHPT or in normal subjects. All morphometric parameters investigated (fractional volume and nuclear density of capillary endothelial cells, volume fraction and number per unit area of capillaries) showed 1.5- to 2-fold higher values in patients with MEN-1 than in those with UHPT (P < 0.05). In contrast, no difference was found between MEN-1 cases and normal subjects. Quantitative evaluation of parathyroid pericytes yielded results similar to those of endothelial cells. These data indicate that the proliferation of parathyroid cells in MEN-1 patients is accompanied by parallel increase in the associated endothelial component that does not occur in patients with UHPT and may support the hypothesis of an in vivo role of the MEN-1 mitogen factor on the endothelial component of parathyroid glands in MEN-1 patients.
- Subjects :
- Adult
Aged
Animals
Blood Proteins pharmacology
Cattle
Cell Division
Cells, Cultured drug effects
Female
Humans
Hyperparathyroidism, Secondary blood
Male
Middle Aged
Multiple Endocrine Neoplasia blood
Multiple Endocrine Neoplasia immunology
Uremia blood
Endothelium, Vascular ultrastructure
Fibroblast Growth Factor 2 pharmacology
Multiple Endocrine Neoplasia ultrastructure
Parathyroid Glands ultrastructure
Subjects
Details
- Language :
- English
- ISSN :
- 0002-9440
- Volume :
- 143
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- The American journal of pathology
- Publication Type :
- Academic Journal
- Accession number :
- 8102033