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Binding of taxol to human plasma, albumin and alpha 1-acid glycoprotein.
- Source :
-
Research communications in chemical pathology and pharmacology [Res Commun Chem Pathol Pharmacol] 1993 Jun; Vol. 80 (3), pp. 337-44. - Publication Year :
- 1993
-
Abstract
- The binding of taxol to human plasma and to individual plasma proteins was studied by equilibrium dialysis. Taxol was found to bind extensively (about 95%) without a significant difference between healthy volunteers and cancer patients. At clinically relevant concentrations (0.1-6 microM), the binding was found to be concentration independent, indicating nonspecific hydrophobic binding. Human serum albumin and alpha 1-acid glycoprotein were found to contribute about equally to the binding, with a minor contribution from lipoproteins. None of the drugs commonly coadministered with taxol (dexamethasone, diphenhydramine, ranitidine, doxorubicin, 5-fluorouracil and cisplatin) altered the binding of taxol significantly. The protein binding of taxol was found to dramatically decrease the red blood cell uptake of taxol.
Details
- Language :
- English
- ISSN :
- 0034-5164
- Volume :
- 80
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Research communications in chemical pathology and pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 8102493