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A retrospective study on the clinical and biological prediction of axillary lymph node metastasis in breast cancer.
- Source :
-
Surgery today [Surg Today] 1993; Vol. 23 (7), pp. 573-9. - Publication Year :
- 1993
-
Abstract
- If axillary lymph node metastases were able to be accurately predicted, dissection could be avoided in some patients with breast cancer whose axillary nodes are clinically negative. In this study, we assessed the relationships between histological axillary lymph node metastases and clinical axillary nodal status, tumor size, DNA-ploidy, c-erbB-2 expression, and the score of the argyrophilic nucleolar organizer region. We then attempted to evaluate their predictive values for axillary lymph node metastasis in 173 patients with invasive breast cancer, retrospectively. The clinical and biological variables were significantly correlated with the presence and degree of axillary lymph node metastases. A metastatic index, calculated from the clinical and biological variables, proved especially useful for predicting axillary lymph node metastases in patients whose axillary nodes were clinically negative. However, the predictive abilities were still limited and thus it was concluded that as yet, only axillary dissection can provide accurate information on axillary lymph node metastases.
- Subjects :
- Adult
Aged
Aged, 80 and over
Axilla
Biomarkers, Tumor analysis
Breast Neoplasms genetics
Breast Neoplasms surgery
Breast Neoplasms ultrastructure
DNA, Neoplasm genetics
Female
Gene Expression
Humans
Lymph Node Excision
Middle Aged
Nucleolus Organizer Region
Ploidies
Predictive Value of Tests
Prognosis
Proto-Oncogene Proteins analysis
Receptor, ErbB-2
Retrospective Studies
Risk Factors
Sensitivity and Specificity
Breast Neoplasms pathology
Lymphatic Metastasis pathology
Subjects
Details
- Language :
- English
- ISSN :
- 0941-1291
- Volume :
- 23
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Surgery today
- Publication Type :
- Academic Journal
- Accession number :
- 8103689
- Full Text :
- https://doi.org/10.1007/BF00311903