Lipopolysaccharide (LPS) inhalation in healthy subjects causes bronchoalveolar neutrophilia, lymphocytosis, and fibronectin increase.

Authors :: Sandström T
Bjermer L
Rylander R
Source :: American journal of industrial medicine [Am J Ind Med] 1994 Jan; Vol. 25 (1), pp. 103-4.
Publication Year :: 1994
Abstract: Eight healthy volunteers were exposed to purified lipopolysaccharide (LPS) by controlled inhalation. Bronchoalveolar lavage (BAL) 3 hours after exposure revealed a pronounced neutrophilia, increase in lymphocytes, fibronectin concentration, and decrease in alveolar macrophage phagocytosis, as compared to a reference BAL.

Subjects :: Administration, Inhalation
Adult
Bronchial Provocation Tests
Dust adverse effects
Fibronectins metabolism
Humans
Inflammation
Leukocyte Count
Lymphocytosis physiopathology
Neutrophils physiology
Bronchoalveolar Lavage Fluid cytology
Bronchoalveolar Lavage Fluid immunology
Escherichia coli
Lipopolysaccharides adverse effects
Lymphocytosis etiology

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