Insulin-secretional effect of exogenic amino acids in rabbits.

D,L-arginine and L-lysine, introduced into the alimentary canal (IAC), caused significant secretion of insulin in rabbits, whereas D,L-methionine or L-phenylalanine evoked only a small effect. Also, intravenous (IV) injection of D,L-arginine caused dose dependent and biphasic insulin output. On the other hand, L-phenylalanine given IV decreased both basal and glucose--stimulated insulin level in blood.