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Activity oscillations predicted for pyruvate dehydrogenase complexes.

Authors :
Selivanov VA
Zakrzhevskaya DT
Goldstein BN
Source :
FEBS letters [FEBS Lett] 1994 May 30; Vol. 345 (2-3), pp. 151-3.
Publication Year :
1994

Abstract

A kinetic model for the pyruvate dehydrogenase complex is analyzed. The model takes into account intermediate channeling through the lipoyl network attached to the complex core, as well as inter-related regulatory effects of protein X acetylation and enzyme phosphorylation. The model predicts undamped oscillations of enzyme activity.

Subjects

Subjects :
Kinetics
Mathematics
Models, Theoretical
Oscillometry
Time Factors
Pyruvate Dehydrogenase Complex metabolism

Details

Language :
English
ISSN :
0014-5793
Volume :
345
Issue :
2-3
Database :
MEDLINE
Journal :
FEBS letters
Publication Type :
Academic Journal
Accession number :
8200448
Full Text :
https://doi.org/10.1016/0014-5793(94)00425-0
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