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In vivo effect of berenil on rat liver polyamine metabolism.

Authors :
Colombatto S
Cravanzola C
Grillo MA
Source :
The International journal of biochemistry [Int J Biochem] 1993 Sep; Vol. 25 (9), pp. 1241-3.
Publication Year :
1993

Abstract

1. Berenil, administered to rats in vivo, promoted a decrease in liver SAMDC activity, but an increase in ODC and SAT activity. 2. Its effect on ODC was completely prevented by cycloheximide, that on SAT only partially. 3. Berenil had no effect on ODC activity in adrenalectomized rats. Adrenergic antagonists counteracted the effect of Berenil on ODC activity. 4. Polyamine content was increased. The maximum modification was observed for putrescine and N1-acetylspermidine.

Subjects

Subjects :
Acetyltransferases drug effects
Animals
Diminazene pharmacology
Liver enzymology
Liver metabolism
Male
Rats
Adenosylmethionine Decarboxylase drug effects
Biogenic Polyamines metabolism
Diminazene analogs & derivatives
Liver drug effects
Ornithine Decarboxylase drug effects

Details

Language :
English
ISSN :
0020-711X
Volume :
25
Issue :
9
Database :
MEDLINE
Journal :
The International journal of biochemistry
Publication Type :
Academic Journal
Accession number :
8224368
Full Text :
https://doi.org/10.1016/0020-711x(93)90073-n
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