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Bis-naphthalimides: a new class of antitumor agents.
- Source :
-
Anti-cancer drug design [Anticancer Drug Des] 1993 Aug; Vol. 8 (4), pp. 257-68. - Publication Year :
- 1993
-
Abstract
- A series of bis-intercalators bearing the 1,8-naphthalimide chromophore has been synthesized and in vitro activities determined. Most compounds have higher activities in HT-29 than the leader compounds Mitonafide and Amonafide. One of them (22) was selected for in vivo studies and presents an interesting activity in MX-1 and OVCAR models. (22) also acts as antitopoisomerase II.
- Subjects :
- Adenine
Animals
Antineoplastic Agents pharmacology
Humans
Imides chemistry
Imides pharmacology
Intercalating Agents pharmacology
Isoquinolines chemistry
Isoquinolines pharmacology
Mice
Naphthalenes chemistry
Naphthalenes pharmacology
Naphthalimides
Neoplasms, Experimental drug therapy
Organophosphonates
Structure-Activity Relationship
Tumor Cells, Cultured drug effects
Antineoplastic Agents chemical synthesis
Imides chemical synthesis
Intercalating Agents chemical synthesis
Isoquinolines chemical synthesis
Naphthalenes chemical synthesis
Subjects
Details
- Language :
- English
- ISSN :
- 0266-9536
- Volume :
- 8
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Anti-cancer drug design
- Publication Type :
- Academic Journal
- Accession number :
- 8240655