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Reduction of food intake and morphine analgesia by central glybenclamide.
- Source :
-
Pharmacology, biochemistry, and behavior [Pharmacol Biochem Behav] 1993 Sep; Vol. 46 (1), pp. 205-7. - Publication Year :
- 1993
-
Abstract
- Previous research has indicated the presence of a reciprocal relationship between food intake and opioid-mediated analgesia. We believe the cellular candidate most likely acting as a common mediator of both ingestive and nociceptive behaviors is the ATP-sensitive K+ channel (K+ATP). This ion channel appears to be opened by mu and delta 1 opioid receptor agonists in the service of analgesia, and closed as cellular ATP availability rises. To further examine the role of the K+ATP in the relationship between feeding and opioid function, we administered 80 nmol of glybenclamide (a K+ATP antagonist) to male SD rats via the lateral ventricle. Chow consumption in the treated animals was significantly reduced over the following 48 h (F = 2.62, p < 0.013), with the peak effect (78% of control) occurring at 6 h. In the tail-flick test, 4 mg/kg morphine sulfate provided analgesia of 42.38 +/- 8.4% and 18.89 +/- 7.67% in vehicle and treated animals, respectively (p < 0.05, n = 8/group, one-tailed t-test). These results support the hypothesis that food intake and analgesia are reciprocally modulated through activity at the K+ATP.
- Subjects :
- Adenosine Triphosphate physiology
Animals
Injections, Intraventricular
Male
Morphine pharmacology
Pain Measurement drug effects
Potassium Channels drug effects
Potassium Channels metabolism
Rats
Rats, Sprague-Dawley
Analgesia
Eating drug effects
Glyburide pharmacology
Morphine antagonists & inhibitors
Subjects
Details
- Language :
- English
- ISSN :
- 0091-3057
- Volume :
- 46
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Pharmacology, biochemistry, and behavior
- Publication Type :
- Academic Journal
- Accession number :
- 8255912
- Full Text :
- https://doi.org/10.1016/0091-3057(93)90341-p