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Peptide translocation by variants of the transporter associated with antigen processing.
- Source :
-
Science (New York, N.Y.) [Science] 1993 Dec 24; Vol. 262 (5142), pp. 2059-63. - Publication Year :
- 1993
-
Abstract
- Major histocompatibility complex (MHC) class I molecules associate with peptides that are delivered from the cytosol to the lumen of the endoplasmic reticulum by the transporter associated with antigen processing (TAP). Liver microsomes of SHR and Lewis rats, which express different alleles of TAP (cim(b) and cim(a), respectively), accumulate different sets of peptides. Use of MHC congenic rats assigned this difference to the MHC, independent of the class I products expressed. Both the cim(a) and cim(b) TAP complexes translocate peptides with a hydrophobic carboxyl terminus, but translocation of peptides with a carboxyl-terminal His, Lys, or Arg residue is unique to cim(a). Thus, the specificity of the TAP peptide translocator restricts the peptides available for antigen presentation.
- Subjects :
- ATP Binding Cassette Transporter, Subfamily B, Member 2
ATP Binding Cassette Transporter, Subfamily B, Member 3
Alleles
Amino Acid Sequence
Animals
Biological Transport physiology
Carrier Proteins genetics
Histocompatibility Antigens Class I physiology
Histocompatibility Antigens Class II genetics
In Vitro Techniques
Microsomes, Liver metabolism
Molecular Sequence Data
Rats
Rats, Inbred BN
Rats, Inbred Lew
Rats, Inbred SHR
Substrate Specificity
ATP-Binding Cassette Transporters
Antigen Presentation physiology
Carrier Proteins physiology
Histocompatibility Antigens Class II physiology
Oligopeptides metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0036-8075
- Volume :
- 262
- Issue :
- 5142
- Database :
- MEDLINE
- Journal :
- Science (New York, N.Y.)
- Publication Type :
- Academic Journal
- Accession number :
- 8266106
- Full Text :
- https://doi.org/10.1126/science.8266106