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WHO Neuropsychiatric AIDS study, cross-sectional phase I. Study design and psychiatric findings.
- Source :
-
Archives of general psychiatry [Arch Gen Psychiatry] 1994 Jan; Vol. 51 (1), pp. 39-49. - Publication Year :
- 1994
-
Abstract
- Background: Most available studies on the psychiatric, neuropsychological, and neurological complications of HIV-1 infection and AIDS have been conducted in Western countries, on samples of well-educated, mostly white, homosexual men. Concerns about generalizability of the results of those investigations prompted the WHO to implement the cross-cultural venture called WHO Neuropsychiatric AIDS study.<br />Methods: This project aims to assess the prevalence and natural history of HIV-1-associated psychiatric, neuropsychological, and neurological abnormalities in representative subject samples enrolled in the five geographic areas predominantly affected by the HIV-1 epidemic. Assessment is made by a data collection instrument including six modules. The intercenter and intracenter reliability in the use of each module has been formally evaluated. The study consists of a cross-sectional phase and a longitudinal follow-up.<br />Results: The cross-sectional phase was completed in five centers. This paper reports on the results of psychiatric assessment, which revealed a significantly higher prevalence of current mental disorders in symptomatic seropositive persons compared with seronegative controls among intravenous drug users in Bangkok and homosexuals/bisexuals in São Paulo. The mean global score on the Montgomery-Asberg Depression Rating Scale was significantly higher in symptomatic seropositive individuals than in matched seronegative controls in all centers.<br />Conclusions: These results suggest that the significance of the psychopathological complications of symptomatic HIV-1 infection may have been underestimated by previous studies conducted on self-selected samples of well-educated, middle-class, mostly white, homosexual men.
- Subjects :
- AIDS Dementia Complex epidemiology
Adult
Bisexuality statistics & numerical data
Brazil epidemiology
Comorbidity
Cross-Sectional Studies
Democratic Republic of the Congo epidemiology
Depressive Disorder epidemiology
Female
Germany epidemiology
HIV Seropositivity epidemiology
Homosexuality statistics & numerical data
Humans
Kenya epidemiology
Male
Prevalence
Psychiatric Status Rating Scales
Thailand epidemiology
World Health Organization
Acquired Immunodeficiency Syndrome epidemiology
Mental Disorders epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 0003-990X
- Volume :
- 51
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Archives of general psychiatry
- Publication Type :
- Academic Journal
- Accession number :
- 8279928
- Full Text :
- https://doi.org/10.1001/archpsyc.1994.03950010039006