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Propofol infusion anaesthesia and immune response in minor surgery.
- Source :
-
Anaesthesia [Anaesthesia] 1994 Jan; Vol. 49 (1), pp. 13-6. - Publication Year :
- 1994
-
Abstract
- This study was set up to evaluate the effects of propofol infusion anaesthesia on immunological function in minor surgery. Twenty-seven patients (median age 51 years, ASA 1-2) scheduled for minor breast surgery were randomly assigned to two groups. Anaesthesia was induced in group 1 with propofol 2.5 mg.kg-1 and maintained with propofol 12 mg.kg-1 x h-1 and 30% O2 in air, whereas in group 2 anaesthesia was induced with thiopentone 4 mg.kg-1 and maintained with 70% N2O in O2. Fentanyl and vecuronium were used in both groups. The percentages of T cells (p < 0.001), B cells (p < 0.01) and memory T cells increased (p < 0.01) in both groups. T helper cell percentages increased in the propofol but not in the thiopentone group (p < 0.05). The percentages of natural killer cells decreased from pre-induction values in both groups (p < 0.001). No changes were seen in lymphocyte proliferative responses. Minor breast surgery under propofol or conventional combined anaesthesia had only minor effects on the immune response. The higher percentage of T helper cells after propofol anaesthesia compared to conventional combined anaesthesia is beneficial, but its clinical importance remains to be determined.
- Subjects :
- Adult
Breast surgery
Cell Division drug effects
Female
Humans
Immunity, Cellular drug effects
Killer Cells, Natural drug effects
Leukocyte Count drug effects
Middle Aged
Mitogens immunology
T-Lymphocytes, Helper-Inducer drug effects
Anesthesia, Intravenous
Lymphocyte Subsets drug effects
Minor Surgical Procedures
Propofol pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0003-2409
- Volume :
- 49
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Anaesthesia
- Publication Type :
- Academic Journal
- Accession number :
- 8311204
- Full Text :
- https://doi.org/10.1111/j.1365-2044.1994.tb03304.x