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Combination chemotherapy using cyclophosphamide, vincristine, methotrexate, 5-fluorouracil, and prednisone in solid tumors.
- Source :
-
Cancer [Cancer] 1977 Jan; Vol. 39 (1), pp. 21-6. - Publication Year :
- 1977
-
Abstract
- Three hundred and ninety-eight patients with disseminated solid tumors other than breast cancer, were treated with a combination chemotherapy protocol utilizing cyclophosphamide, vincristine sulfate, methotrexate, 5-fluorouracil, and prednisone. Three hundred and eighty were evaluable (95.5%). Partial or complete tumor regressions were noted in 73 of 380 (19%) evaluable patients. Response to therapy was associated with a prolongation and survival. The largest tumor categories were lung, ovary, and gastrointestinal. The proportion of complete plus partial responses in evaluable lung cancer patients was 40/236 (17%), compared to 20/44 (45%) for ovarian cancer patients and 6/39 (15%) for gastrointestinal tumors. Of the patients who could be evaluated for toxicity, 47% had minimal or no toxicity, 51% had moderate to severe toxicity, and 2% had life threatening toxicity. Virtually all patients were treated and managed as outpatients.
- Subjects :
- Drug Therapy, Combination
Female
Gastrointestinal Neoplasms drug therapy
Humans
Leukocyte Count
Lung Neoplasms drug therapy
Male
Neoplasms mortality
Ovarian Neoplasms drug therapy
Remission, Spontaneous
Time Factors
Cyclophosphamide therapeutic use
Fluorouracil therapeutic use
Methotrexate therapeutic use
Neoplasms drug therapy
Prednisone therapeutic use
Vincristine therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 0008-543X
- Volume :
- 39
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Cancer
- Publication Type :
- Academic Journal
- Accession number :
- 832235
- Full Text :
- https://doi.org/10.1002/1097-0142(197701)39:1<21::aid-cncr2820390105>3.0.co;2-i