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In vitro activity of cefodizime (HR-221) in combination with beta-lactamase inhibitors.
In vitro activity of cefodizime (HR-221) in combination with beta-lactamase inhibitors.
- Source :
-
Journal of chemotherapy (Florence, Italy) [J Chemother] 1993 Jun; Vol. 5 (3), pp. 147-50. - Publication Year :
- 1993
-
Abstract
- Cefodizime (formerly HR221) was tested either for in vitro microbiological activity or for its stability to beta-lactamases in the presence of two beta-lactamase inhibitors (clavulanic acid, tazobactam). Cefodizime was a poor substrate of class C enzymes but hyperproducer strains were generally resistant with or without a beta-lactamase inhibitor used in combination. On the contrary, class A enzymes were able to hydrolyze cefodizime. However, strains expressing class A beta-lactamase were susceptible to cefodizime in combination with clavulanic acid.
- Subjects :
- Cefotaxime antagonists & inhibitors
Cefotaxime pharmacology
Clavulanic Acid
Drug Combinations
Drug Interactions
Drug Stability
Humans
Microbial Sensitivity Tests
Tazobactam
Anti-Bacterial Agents pharmacology
Bacteria drug effects
Cefotaxime analogs & derivatives
Clavulanic Acids pharmacology
Penicillanic Acid pharmacology
beta-Lactamase Inhibitors
Subjects
Details
- Language :
- English
- ISSN :
- 1120-009X
- Volume :
- 5
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Journal of chemotherapy (Florence, Italy)
- Publication Type :
- Academic Journal
- Accession number :
- 8396624
- Full Text :
- https://doi.org/10.1080/1120009x.1993.11739223