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In vitro activity of cefodizime (HR-221) in combination with beta-lactamase inhibitors.

In vitro activity of cefodizime (HR-221) in combination with beta-lactamase inhibitors.

Authors :
Segatore B
Perilli M
Franceschini N
Setacci D
Oratore A
Amicosante G
Source :
Journal of chemotherapy (Florence, Italy) [J Chemother] 1993 Jun; Vol. 5 (3), pp. 147-50.
Publication Year :
1993

Abstract

Cefodizime (formerly HR221) was tested either for in vitro microbiological activity or for its stability to beta-lactamases in the presence of two beta-lactamase inhibitors (clavulanic acid, tazobactam). Cefodizime was a poor substrate of class C enzymes but hyperproducer strains were generally resistant with or without a beta-lactamase inhibitor used in combination. On the contrary, class A enzymes were able to hydrolyze cefodizime. However, strains expressing class A beta-lactamase were susceptible to cefodizime in combination with clavulanic acid.

Details

Language :
English
ISSN :
1120-009X
Volume :
5
Issue :
3
Database :
MEDLINE
Journal :
Journal of chemotherapy (Florence, Italy)
Publication Type :
Academic Journal
Accession number :
8396624
Full Text :
https://doi.org/10.1080/1120009x.1993.11739223