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Attenuation of hypercortisolemia in fawn-hooded rats by antidepressant drugs.

Authors :
Aulakh CS
Hill JL
Murphy DL
Source :
European journal of pharmacology [Eur J Pharmacol] 1993 Aug 10; Vol. 240 (1), pp. 85-8.
Publication Year :
1993

Abstract

Long-term (21 days) treatment with imipramine, clomipramine (tricyclic antidepressants) and clorgyline (monoamine-oxidase type A inhibiting antidepressant) produced significant decreases in plasma corticosterone levels in fawn-hooded (FH) rats. In contrast, plasma adrenocorticotropic hormone (ACTH) levels were not altered by chronic imipramine or clorgyline treatment but were significantly higher in chronic clomipramine-treated FH rats. These findings demonstrate a differential effect of chronic antidepressant treatment on plasma ACTH and corticosterone concentrations in FH rats and, furthermore, support the results of earlier studies suggesting that the FH rat strain may represent a genetic model of depression.

Details

Language :
English
ISSN :
0014-2999
Volume :
240
Issue :
1
Database :
MEDLINE
Journal :
European journal of pharmacology
Publication Type :
Academic Journal
Accession number :
8405126
Full Text :
https://doi.org/10.1016/0014-2999(93)90550-2