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Immunoglobulin G subclass responses to mycobacterial lipoarabinomannan in HIV-infected and non-infected patients with tuberculosis.
- Source :
-
Clinical and experimental immunology [Clin Exp Immunol] 1993 Jan; Vol. 91 (1), pp. 25-9. - Publication Year :
- 1993
-
Abstract
- Immunoglobulin G subclass responses to lipoarabinomannan (LAM) of Mycobacterium tuberculosis were determined by ELISA in both HIV-1 antibody positive (n = 31) and negative (n = 43) patients with tuberculosis (TB). Responses were also studied in a group of healthy controls (n = 16) and HIV-1 antibody positive (n = 60) individuals without TB. IgG2 antibodies were the predominant subclass, being present in 25 of 43 non-HIV-infected TB patients (58%) and in 11 of 31 HIV-infected TB patients (35%). However, HIV+ TB patients also showed IgG4 (n = 16; 52%), and IgG1 (n = 4, 13%) responses to LAM, whereas these subclasses were absent in sera from HIV-TB patients. Individuals in both non-tuberculous control groups showed no antibody responses to LAM. The influence of HIV infection on B cell responses to LAM, and possible mechanisms for antibody-mediated regulation of immunity to TB, are explored.
- Subjects :
- Adolescent
Adult
Female
HIV Infections complications
Humans
Immunoglobulin G classification
Male
Sex Factors
Tuberculosis, Pulmonary complications
Antigens, Bacterial immunology
HIV Infections immunology
Immunoglobulin G analysis
Lipopolysaccharides immunology
Mycobacterium immunology
Tuberculosis, Pulmonary immunology
Subjects
Details
- Language :
- English
- ISSN :
- 0009-9104
- Volume :
- 91
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Clinical and experimental immunology
- Publication Type :
- Academic Journal
- Accession number :
- 8419082
- Full Text :
- https://doi.org/10.1111/j.1365-2249.1993.tb03348.x