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Vasopressin- and oxytocin-immunoreactive hypothalamic neurones of inbred polydipsic mice.
- Source :
-
Brain research bulletin [Brain Res Bull] 1993; Vol. 31 (3-4), pp. 405-14. - Publication Year :
- 1993
-
Abstract
- In the late 1950s the inbred polydipsic mice, STR/N, was discovered. The early studies indicated that the extreme polydipsia was not due to a lack of vasopressin but probably due to innate thirst of unknown origin. Because the recent investigation has revealed the presence of some functional abnormality in the brain of the STR/N mouse, we now investigated, using immunohistochemical techniques, distribution of vasopressin (AVP)- and oxytocin (OXT)-containing neurones in the hypothalamus of polydipsic strain of mouse and compared with that of the control. The pattern of distribution of AVP- and OXT-immunoreactive neurones in the paraventricular (PV), supraoptic (SO), and suprachiasmatic nuclei (SCN) of the STR/N polydipsic mouse was similar to that of the control, but the number of AVP-immunoreactive neurones was more numerous in the PVN and SON and less in the SCN in the polydipsic mouse than in the control. In addition, a discrete group of AVP- and OXT-containing neurones that was not clearly seen in the control was discovered in the STR/N. These results implicate that abnormal distribution in the brain AVP and OXT contribute to the mechanism responsible for the polydipsia shown by the strain STR/N.
- Subjects :
- Animals
Arginine Vasopressin immunology
Cerebral Ventricles anatomy & histology
Female
Hypothalamus immunology
Immunohistochemistry
Male
Mice
Mice, Inbred ICR
Mutation
Neurons immunology
Oxytocin immunology
Arginine Vasopressin pharmacology
Drinking Behavior physiology
Hypothalamus metabolism
Neurons metabolism
Oxytocin pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0361-9230
- Volume :
- 31
- Issue :
- 3-4
- Database :
- MEDLINE
- Journal :
- Brain research bulletin
- Publication Type :
- Academic Journal
- Accession number :
- 8490739
- Full Text :
- https://doi.org/10.1016/0361-9230(93)90234-3