Mathematical modeling of T-cell proliferation.

A mathematical model of the T-lymphocyte proliferation process (in vivo and in vitro) is presented. This model takes into account cell-cycle progression and the regulation by lymphokines (lymphocyte activating factor interleukin 1 and T-cell growth factor interleukin 2). Using data on the generalized picture of the short-term course of viral hepatitis B, the parameter estimation procedure is carried out. The possibility of immunocorrection (by means of injection of a pharmacologic dose of IL-2) during the immune response to viral hepatitis B with T-lymphocyte deficiency is shown.