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The activity of an analogue of MPF (beta-endorphin 28-31) in a rat model of Parkinson's disease.
- Source :
-
Brain research [Brain Res] 1993 Apr 30; Vol. 610 (1), pp. 166-8. - Publication Year :
- 1993
-
Abstract
- A single intrastriatal injection of a slow release formulation of a metabolically-stable MPF analogue was given to rats with lesioned right nigrostriatal pathways. After 6 weeks the turning behaviour of the rats in response to D-amphetamine began to decline, and after 12 weeks the reduction was marked and consistent. The implication of our results in the use of intracerebral grafts in parkinsonian patients is discussed.
Details
- Language :
- English
- ISSN :
- 0006-8993
- Volume :
- 610
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Brain research
- Publication Type :
- Academic Journal
- Accession number :
- 8518925
- Full Text :
- https://doi.org/10.1016/0006-8993(93)91232-h