The activity of an analogue of MPF (beta-endorphin 28-31) in a rat model of Parkinson's disease.

Authors :: Ensor DM
Morley JS
Redfern RM
Miles JB
Source :: Brain research [Brain Res] 1993 Apr 30; Vol. 610 (1), pp. 166-8.
Publication Year :: 1993
Abstract: A single intrastriatal injection of a slow release formulation of a metabolically-stable MPF analogue was given to rats with lesioned right nigrostriatal pathways. After 6 weeks the turning behaviour of the rats in response to D-amphetamine began to decline, and after 12 weeks the reduction was marked and consistent. The implication of our results in the use of intracerebral grafts in parkinsonian patients is discussed.

Subjects :: Amino Acid Sequence
Animals
Delayed-Action Preparations
Disease Models, Animal
Male
Molecular Sequence Data
Rats
Rats, Wistar
beta-Endorphin administration & dosage
Parkinson Disease drug therapy
Peptide Fragments administration & dosage
beta-Endorphin analogs & derivatives

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