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C-C chemokines, but not the C-X-C chemokines interleukin-8 and interferon-gamma inducible protein-10, stimulate transendothelial chemotaxis of T lymphocytes.
- Source :
-
European journal of immunology [Eur J Immunol] 1995 Dec; Vol. 25 (12), pp. 3482-8. - Publication Year :
- 1995
-
Abstract
- Eight chemokines were tested for ability to elicit transendothelial chemotaxis of unstimulated peripheral blood T lymphocytes. The C-C chemokines monocyte chemotactic protein (MCP)-2, MCP-3, RANTES, macrophage inflammatory protein (MIP)-1 alpha, MIP-1 beta, and, as previously described, MCP-1 induced significant, dose-dependent transendothelial chemotaxis of CD3+ T lymphocytes. In contrast, the C-X-C chemokines interleukin-8 (IL-8) and interferon-gamma inducible protein-10 (IP-10) failed to induce transendothelial chemotaxis of CD3+ T lymphocytes or T lymphocyte subsets. RANTES, MIP-1 alpha, and MIP-1 beta induced significant transendothelial chemotaxis of CD4+, CD8+, and CD45R0+ T lymphocyte subsets. Phenotyping of mononuclear cells that underwent transendothelial migration to MCP-2, MCP-3, RANTES, or MIP-1 alpha showed both monocytes and activated (CD26 high), memory-type (CD45R0+) T cells. Both CD4+ and CD8+ T lymphocytes were recruited, but not natural killer cells or significant numbers of B cells. MCP-2 was the only C-C chemokine tested that attracted a significant number of naive-type (CD45RA+) T lymphocytes. In the absence of endothelium, IL-8 but not IP-10 promoted modest but significant chemotoxis of CD3+ T lymphocytes. Our data support the hypothesis that C-C, not the C-X-C chemokines IL-8 or IP-10, promote transendothelial chemotaxis of T lymphocytes.
- Subjects :
- CD3 Complex physiology
CD4-Positive T-Lymphocytes physiology
CD8-Positive T-Lymphocytes physiology
Chemokine CCL7
Chemokine CCL8
Chemokine CXCL10
Chemokines chemistry
Chemotaxis, Leukocyte immunology
Cytokines biosynthesis
Cytokines chemistry
Humans
Immunophenotyping
Interleukin-8 chemistry
Leukocyte Common Antigens physiology
Membranes, Artificial
Monocyte Chemoattractant Proteins pharmacology
T-Lymphocyte Subsets classification
Chemokines pharmacology
Chemokines, CXC
Chemotaxis, Leukocyte drug effects
Cytokines pharmacology
Endothelium, Vascular immunology
Interferon-gamma pharmacology
Interleukin-8 pharmacology
T-Lymphocyte Subsets physiology
Subjects
Details
- Language :
- English
- ISSN :
- 0014-2980
- Volume :
- 25
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- European journal of immunology
- Publication Type :
- Academic Journal
- Accession number :
- 8566041
- Full Text :
- https://doi.org/10.1002/eji.1830251241