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Renoprotective effect of enalapril in uninephrectomized spontaneously hypertensive rats with neonatal streptozotocin-induced diabetes.
- Source :
-
Diabetes research and clinical practice [Diabetes Res Clin Pract] 1995 Sep; Vol. 29 (3), pp. 153-61. - Publication Year :
- 1995
-
Abstract
- We compared the renoprotective effect between angiotensin-converting enzyme inhibitor, enalapril, and a dihydropyridine-type calcium channel blocker, nicardipine, in a severe form of renal injury in rats. Two-day-old spontaneously hypertensive rats (SHR) were injected with streptozotocin or vehicle as control. UNX was performed at 3 weeks of age, and enalapril or nicardipine was administered in drinking water from 7 weeks of age. Uninephrectomy (UNX) markedly exacerbated hypertension and renal injury in the nondiabetic and diabetic SHR. Enalapril and nicardipine comparably reduced blood pressure in UNX diabetic SHR. However, serum creatinine was significantly elevated in the nicardipine-treated group as compared with the enalapril-treated group at 24 weeks of age (nicardipine-treated group, 67 +/- 4 microM; enalapril-treated group, 49 +/- 3 microM; P < 0.01; untreated group 57 +/- 4 microM). Furthermore, the incidence of glomerular sclerosis was similar between untreated and nicardipine-treated groups, whereas it tended to be reduced in the enalapril-treated group. In a separate experiment of diabetic SHR without UNX, enalapril therapy significantly ameliorated hyperglycemia and albuminuria (P < 0.01). This study showed that a renoprotective effect was seen in enalapril but not in nicardipine in UNX diabetic SHR despite the comparable reduction of blood pressure. This suggests that enalapril may be more effective than nicardipine in delaying the progression of a severe form of diabetic nephropathy.
- Subjects :
- Analysis of Variance
Animals
Animals, Newborn
Calcium Channel Blockers therapeutic use
Diabetes Mellitus, Experimental complications
Hypertension complications
Male
Nephrectomy
Nicardipine therapeutic use
Organ Size drug effects
Rats
Rats, Inbred SHR
Angiotensin-Converting Enzyme Inhibitors therapeutic use
Antihypertensive Agents therapeutic use
Diabetes Mellitus, Experimental drug therapy
Diabetic Nephropathies prevention & control
Enalapril therapeutic use
Hypertension drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 0168-8227
- Volume :
- 29
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Diabetes research and clinical practice
- Publication Type :
- Academic Journal
- Accession number :
- 8591707
- Full Text :
- https://doi.org/10.1016/0168-8227(95)01135-8