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Basic fibroblast growth factor restores endothelium-dependent responses after balloon injury of rabbit arteries.
- Source :
-
Circulation [Circulation] 1996 Jan 01; Vol. 93 (1), pp. 18-22. - Publication Year :
- 1996
-
Abstract
- Background: After experimental angioplasty, partial or complete reendothelialization of the denuded surface occurs; the function of the regenerated endothelium has, however, been shown to be abnormal. Basic fibroblast growth factor (bFGF) is mitogenic for endothelial cells in vitro and in vivo. We investigated whether chronic administration of bFGF in a rabbit model of balloon denudation might not only improve endothelial regrowth but also restore normal physiological responses to endothelium-dependent agonists.<br />Methods and Results: Thirty-nine New Zealand White rabbits underwent balloon denudation of the right iliac artery. Twenty rabbits received intravenous administration of bFGF (2.5 micrograms twice a week for 2 weeks). Nineteen rabbits receiving saline injections served as controls. Animals were killed on day 28 for assessment of reendothelialization and neointimal thickening and for analysis of in vitro vasoreactivity. Animals in the bFGF group had a significantly (P<.005) greater degree of reendothelialization than controls (115 +/- 13 versus 55 +/- 6 mm2). Neointimal thickening was similar in the two groups. Four weeks after denudation, endothelium-independent responses did not differ significantly between the two groups. In contrast, the maximal endothelium-dependent acetylcholine-induced relaxation of the bFGF-treated animals (Emax, 40 +/- 7%) was significantly greater than that of the control group (Emax, 11 +/- 9%; P<.05).<br />Conclusions: Systemic administration of bFGF restores, in large part, the responses of previously denuded arterial segments to endothelium-dependent vasodilators. Angiogenic growth factors may help to reestablish normal endothelial cell function in patients who have undergone angioplasty.
- Subjects :
- Acetylcholine pharmacology
Animals
Catheterization
Cell Division drug effects
Endothelium, Vascular drug effects
Endothelium, Vascular pathology
Iliac Artery drug effects
Iliac Artery pathology
Male
Rabbits
Tunica Intima physiology
Vasodilation drug effects
Endothelium, Vascular physiology
Fibroblast Growth Factor 2 pharmacology
Iliac Artery physiology
Phenylephrine pharmacology
Vasoconstrictor Agents pharmacology
Vasodilation physiology
Subjects
Details
- Language :
- English
- ISSN :
- 0009-7322
- Volume :
- 93
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Circulation
- Publication Type :
- Academic Journal
- Accession number :
- 8616926
- Full Text :
- https://doi.org/10.1161/01.cir.93.1.18