Back to Search Start Over

Comparison of the IgE titers to bovine colostral G immunoglobulins and their F(ab')2 fragments in sera of patients allergic to milk.

Authors :
Lefranc-Millot C
Vercaigne-Marko D
Wal JM
LeprĂȘtre A
Peltre G
Dhulster P
Guillochon D
Source :
International archives of allergy and immunology [Int Arch Allergy Immunol] 1996 Jun; Vol. 110 (2), pp. 156-62.
Publication Year :
1996

Abstract

Colostral G immunoglobulins (IgGs) are described in many recent studies as having a beneficial effect for the treatment of viral, bacterial and parasitic diarrhea in animals and humans. The specific IgE titers to bovine colostral IgG, to bovine serum IgG, and to F(ab')2 fragments of IgG were immunoenzymatically quantified in sera of patients allergic to milk, to statistically evaluate and compare their relative immunoreactivity towards these purified antigens. The results clearly indicated that 36% of the population tested was potentially allergic to colostral IgG, and serum IgG globally elicited significantly lower IgE titers. The F(ab')2 fragments lead to a significantly decreased immunoreactivity as compared to colostral IgG. This study shows the interesting use of peptic hydrolysis of IgG in producing fragments with preserved therapeutic immunoactivity and reduced potential allergenicity.

Details

Language :
English
ISSN :
1018-2438
Volume :
110
Issue :
2
Database :
MEDLINE
Journal :
International archives of allergy and immunology
Publication Type :
Academic Journal
Accession number :
8645993
Full Text :
https://doi.org/10.1159/000237280