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Renal and neuronal abnormalities in mice lacking GDNF.
- Source :
-
Nature [Nature] 1996 Jul 04; Vol. 382 (6586), pp. 76-9. - Publication Year :
- 1996
-
Abstract
- Glial cell-line derived neurotrophic factor (GDNF) is a potent survival factor for embryonic midbrain dopaminergic, spinal motor, cranial sensory, sympathetic, and hindbrain noradrenergic neurons, and is available to these cells in vivo. It is therefore considered a physiological trophic factor and a potential therapeutic agent for Parkinson's disease, amyotrophic lateral sclerosis, and Alzheimer's disease. Here we show that at postnatal day 0 (P0), GDNF-deficient mice have deficits in dorsal root ganglion, sympathetic and nodose neurons, but not in hindbrain noradrenergic or midbrain dopaminergic neurons. These mice completely lack the enteric nervous system (ENS), ureters and kidneys. Thus GDNF is important for the development and/or survival of enteric, sympathetic and sensory neurons and the renal system, but is not essential for catecholaminergic neurons in the central nervous system (CNS).
- Subjects :
- Animals
Brain cytology
Brain embryology
Cell Count
Cell Differentiation genetics
Cell Differentiation physiology
Cell Line
Cell Survival
Digestive System innervation
Digestive System Abnormalities
Dopamine metabolism
Gene Targeting
Glial Cell Line-Derived Neurotrophic Factor
In Situ Hybridization
Kidney abnormalities
Mice
Mice, Inbred C57BL
Motor Neurons cytology
Nerve Growth Factors deficiency
Nerve Growth Factors genetics
Nerve Tissue Proteins deficiency
Nerve Tissue Proteins genetics
Neurons metabolism
RNA, Messenger metabolism
Ureter embryology
Digestive System embryology
Kidney embryology
Nerve Growth Factors physiology
Nerve Tissue Proteins physiology
Neurons cytology
Subjects
Details
- Language :
- English
- ISSN :
- 0028-0836
- Volume :
- 382
- Issue :
- 6586
- Database :
- MEDLINE
- Journal :
- Nature
- Publication Type :
- Academic Journal
- Accession number :
- 8657308
- Full Text :
- https://doi.org/10.1038/382076a0