[Colchicinoids--their toxicity and biological activity].

The cytotoxicity of 32 colchicinoids in isolated rat hepatocytes was studied. Their effect was examined by biochemical parameters-lactate dehydrogenase, alanine aminotransferase, aspartate aminotransferase, lipid peroxidation and by changes in reduced glutathione level. Only compounds with methylsulfonyl group at C-10 were significantly hepatotoxic.