Back to Search Start Over

Identification of a mouse eosinophil receptor for the CC chemokine eotaxin.

Identification of a mouse eosinophil receptor for the CC chemokine eotaxin.

Authors :
Gao JL
Sen AI
Kitaura M
Yoshie O
Rothenberg ME
Murphy PM
Luster AD
Source :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 1996 Jun 25; Vol. 223 (3), pp. 679-84.
Publication Year :
1996

Abstract

The CC chemokine eotaxin is a selective chemoattractant for eosinophils in vitro and induces eosinophil migration in vivo. Here we show that the mouse orphan receptor previously named macrophage inflammatory protein-1 alpha receptor-like 2 is a functional eotaxin receptor. For consistency with other nomenclature, we have renamed the receptor mouse CC chemokine receptor 3. Human and mouse eotaxin, but not other chemokines, induced transient increases in [Ca2+]i in human embryonic kidney 293 cells expressing the receptor. RNA for the receptor was abundant in primary eosinophils, but at low levels in neutrophils and macrophages. These properties make this receptor the best known candidate to mediate mouse eosinophil responses to eotaxin.

Details

Language :
English
ISSN :
0006-291X
Volume :
223
Issue :
3
Database :
MEDLINE
Journal :
Biochemical and biophysical research communications
Publication Type :
Academic Journal
Accession number :
8687456
Full Text :
https://doi.org/10.1006/bbrc.1996.0955