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Identification of a mouse eosinophil receptor for the CC chemokine eotaxin.
Identification of a mouse eosinophil receptor for the CC chemokine eotaxin.
- Source :
-
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 1996 Jun 25; Vol. 223 (3), pp. 679-84. - Publication Year :
- 1996
-
Abstract
- The CC chemokine eotaxin is a selective chemoattractant for eosinophils in vitro and induces eosinophil migration in vivo. Here we show that the mouse orphan receptor previously named macrophage inflammatory protein-1 alpha receptor-like 2 is a functional eotaxin receptor. For consistency with other nomenclature, we have renamed the receptor mouse CC chemokine receptor 3. Human and mouse eotaxin, but not other chemokines, induced transient increases in [Ca2+]i in human embryonic kidney 293 cells expressing the receptor. RNA for the receptor was abundant in primary eosinophils, but at low levels in neutrophils and macrophages. These properties make this receptor the best known candidate to mediate mouse eosinophil responses to eotaxin.
- Subjects :
- Animals
Bone Marrow Cells
Calcium metabolism
Cell Line
Cells, Cultured
Chemokine CCL11
Chemotactic Factors, Eosinophil metabolism
Eosinophils cytology
Female
Gene Expression
Humans
Kidney
Macrophages
Mast Cells metabolism
Mice
Mice, Inbred Strains
Receptors, CCR3
Recombinant Proteins biosynthesis
Transfection
Chemokines, CC
Cytokines metabolism
Eosinophils immunology
Receptors, Chemokine
Receptors, Cytokine biosynthesis
Subjects
Details
- Language :
- English
- ISSN :
- 0006-291X
- Volume :
- 223
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Biochemical and biophysical research communications
- Publication Type :
- Academic Journal
- Accession number :
- 8687456
- Full Text :
- https://doi.org/10.1006/bbrc.1996.0955