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bcl-w, a novel member of the bcl-2 family, promotes cell survival.
- Source :
-
Oncogene [Oncogene] 1996 Aug 15; Vol. 13 (4), pp. 665-75. - Publication Year :
- 1996
-
Abstract
- The prototypic mammalian regulator of cell death is bcl-2, the oncogene implicated in the development of human follicular lymphoma. Several homologues of bcl-2 are now known. Using a PCR-based strategy we cloned a novel member of this gene family, denoted bcl-w. The gene, which is highly conserved between mouse and human, resides near the T-cell antigen receptor alpha gene within the central portion of mouse chromosome 14 and on human chromosome 14 at band q11. Enforced expression of bcl-w rendered lymphoid and myeloid cells refractory to several (but not all) cytotoxic conditions. Thus, like Bcl-2 and Bcl-x, the Bcl-w protein promotes cell survival, in contrast to other close homologues, Bax and Bak, which facilitate cell death. Comparison of the expected amino acid sequence of Bcl-w with that of these relatives helps to delineate residues likely to convey survival or anti-survival function. While expression of bcl-w was uncommon in B or T lymphoid cell lines, the mRNA was observed in almost all murine myeloid cell lines analysed and in a wide range of tissues. These findings suggest that bcl-w participates in the control of apoptosis in multiple cell types. Its functional similarity to bcl-2 also makes it an attractive candidate proto-oncogene.
- Subjects :
- Amino Acid Sequence
Animals
Apoptosis Regulatory Proteins
Base Sequence
Cell Survival
Chromosome Mapping
Chromosomes, Human, Pair 14
Cloning, Molecular
DNA, Complementary
Female
Humans
Male
Mice
Mice, Inbred C57BL
Molecular Sequence Data
Multigene Family
Proteins physiology
Proto-Oncogene Mas
Proto-Oncogene Proteins c-bcl-2
Sequence Homology, Amino Acid
Proteins genetics
Proto-Oncogene Proteins genetics
Subjects
Details
- Language :
- English
- ISSN :
- 0950-9232
- Volume :
- 13
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Oncogene
- Publication Type :
- Academic Journal
- Accession number :
- 8761287