Naphthalene sulfonate polymers with CD4-blocking and anti-human immunodeficiency virus type 1 activities.

Authors :: Rusconi S
Moonis M
Merrill DP
Pallai PV
Neidhardt EA
Singh SK
Willis KJ
Osburne MS
Profy AT
Jenson JC
Hirsch MS
Source :: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 1996 Jan; Vol. 40 (1), pp. 234-6.
Publication Year :: 1996
Abstract: PIC 024-4 and PRO 2000 are naphthalene sulfonate polymers that bind to CD4 with nanomolar affinity and block binding of gp120. Both have activity against human immunodeficiency virus type 1 in H9 cells, peripheral blood mononuclear cells, and primary monocyte/macrophages, are synergistic with zidovudine, and do not inhibit tetanus toxoid-stimulated T-cell proliferation at anti-human immunodeficiency virus type 1 concentrations.

Subjects :: Animals
Binding, Competitive
CD4-Positive T-Lymphocytes drug effects
Cell Line, Transformed
Humans
Macaca fascicularis
Naphthalenesulfonates toxicity
Polymers pharmacology
Protein Binding drug effects
Rats
Recombinant Proteins drug effects
Antiviral Agents pharmacology
CD4 Antigens drug effects
HIV Envelope Protein gp120 drug effects
HIV-1 drug effects
Naphthalenesulfonates pharmacology

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