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Combinatorial control of muscle development by basic helix-loop-helix and MADS-box transcription factors.
- Source :
-
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 1996 Sep 03; Vol. 93 (18), pp. 9366-73. - Publication Year :
- 1996
-
Abstract
- Members of the MyoD family of muscle-specific basic helix-loop-helix (bHLH) proteins function within a genetic pathway to control skeletal muscle development. Mutational analyses of these factors suggested that their DNA binding domains mediated interaction with a coregulator required for activation of muscle-specific transcription. Members of the myocyte enhancer binding factor 2 (MEF2) family of MADS-box proteins are expressed at high levels in muscle and neural cells and at lower levels in several other cell types. MEF2 factors are unable to activate muscle gene expression alone, but they potentiate the transcriptional activity of myogenic bHLH proteins. This potentiation appears to be mediated by direct interactions between the DNA binding domains of these different types of transcription factors. Biochemical and genetic evidence suggests that MEF2 factors are the coregulators for myogenic bHLH proteins. The presence of MEF2 and cell-specific bHLH proteins in other cell types raises the possibility that these proteins may also cooperate to regulate other programs of cell-specific gene expression. We present a model to account for such cooperative interactions.
- Subjects :
- Amino Acid Sequence
Animals
Basic Helix-Loop-Helix Transcription Factors
DNA metabolism
DNA-Binding Proteins genetics
DNA-Binding Proteins metabolism
Drosophila
Drosophila Proteins
MEF2 Transcription Factors
Molecular Sequence Data
Muscle, Skeletal cytology
Myogenic Regulatory Factors genetics
Myogenin genetics
Myogenin metabolism
Transcription Factors genetics
Transcription Factors metabolism
Gene Expression Regulation, Developmental
Helix-Loop-Helix Motifs
Muscle, Skeletal embryology
Myogenic Regulatory Factors metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0027-8424
- Volume :
- 93
- Issue :
- 18
- Database :
- MEDLINE
- Journal :
- Proceedings of the National Academy of Sciences of the United States of America
- Publication Type :
- Academic Journal
- Accession number :
- 8790335
- Full Text :
- https://doi.org/10.1073/pnas.93.18.9366