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Association study of dopamine D3 receptor gene and schizophrenia.

Authors :
Kennedy JL
Billett EA
Macciardi FM
Verga M
Parsons TJ
Meltzer HY
Lieberman J
Buchanan JA
Source :
American journal of medical genetics [Am J Med Genet] 1995 Dec 18; Vol. 60 (6), pp. 558-62.
Publication Year :
1995

Abstract

Several groups have reported an association between schizophrenia and the MscI polymorphism in the first exon of the dopamine D3 receptor gene (DRD3). We studied this polymorphism using a North American sample (117 patients plus 188 controls) and an Italian sample (97 patients plus 64 controls). In the first part of the study, we compared allele frequencies of schizophrenia patients and unmatched controls and observed a significant difference in the total sample (P = 0.01). The second part of the study involved a case control approach in which each schizophrenia patient was matched to a control of the same sex, and of similar age and ethnic background. The DRD3 allele frequencies of patients and controls revealed no significant difference between the two groups in the Italian (N = 53) or the North American (N = 54) matched populations; however, when these two matched samples were combined, a significant difference was observed (P = 0.026). Our results suggest that the MscI polymorphism may be associated with schizophrenia in the populations studied.

Details

Language :
English
ISSN :
0148-7299
Volume :
60
Issue :
6
Database :
MEDLINE
Journal :
American journal of medical genetics
Publication Type :
Academic Journal
Accession number :
8825896
Full Text :
https://doi.org/10.1002/ajmg.1320600615