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Role of IFN gamma on TNF alpha, IL-1 beta and IL-6 release during HHV-6 infection.
- Source :
-
The new microbiologica [New Microbiol] 1996 Jul; Vol. 19 (3), pp. 183-91. - Publication Year :
- 1996
-
Abstract
- The release of monokines such as Tumor Necrosis Factor a (TNF alpha), Interleukin-1 beta (IL-1 beta) and Interleukin-6 (IL-6) by activated monocytes/macrophages is an important step in the immune as well as in the inflammatory response. In this study the production of TNF alpha, IL-1 beta and IL-6 by human monocytes (HM) and peripheral blood mononuclear cells (PBMC) was evaluated after HHV-6 infection. Our results demonstrate that HHV-6 can selectively regulate monokine synthesis, in a time-dependent manner. Moreover, we observed a different response closely related to the cellular population (HM or PBMC) examined. The hypothesis we evaluated was that IFN gamma is an important factor triggering the activation of HHV-6 infected human monocytes, to release monokines.
- Subjects :
- Adjuvants, Immunologic pharmacology
Cells, Cultured
Humans
Interleukin-1 biosynthesis
Interleukin-6 biosynthesis
Leukocytes, Mononuclear drug effects
Leukocytes, Mononuclear virology
Monocytes drug effects
Monocytes virology
Propionibacterium acnes
Tumor Necrosis Factor-alpha biosynthesis
Cytokines biosynthesis
Herpesvirus 6, Human metabolism
Interferon-gamma pharmacology
Leukocytes, Mononuclear immunology
Monocytes immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1121-7138
- Volume :
- 19
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- The new microbiologica
- Publication Type :
- Academic Journal
- Accession number :
- 8841033